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. 2021 Apr 15;16(4):e0249555. doi: 10.1371/journal.pone.0249555

Table 2. Risk factors for preeclampsia in twin pregnancies from univariate analysis.

Risk Factor No preeclampsia (n = 516) Preeclampsia (n = 172) OR (95% CI)
Nulliparity 309 (59.6%) 118 (68.6%) 1.46 (1.01–2.11)
Elderly gravidarum 151 (29.2%) 53 (30.8%) 1.08 (0.73–1.59)
Previous preeclampsia 1 (0.2%) 2 (1.2%) 6.06 (0.55–67.24)
Aspirin use during ANC 16 (3.1%) 4 (2.3%) 0.75 (0.25–2.27)
IVF 84 (16.3%) 38 (22.2%) 1.47 (0.95–2.25)
Egg donation 1 (0.2%) 2 (1.2%) 6.06 (0.55–67.24)
Chronic hypertension 5 (1.0%) 12 (7.0%) 7.66 (2.66–22.09)
Gestational diabetes 31 (6.0%) 10 (5.8%) 0.97 (0.43–2.11)
Late ANC 211 (40.9%) 64 (37.2%) 0.86 (0.59–1.24)
Obesity 82 (15.9%) 37 (21.5%) 1.45 (0.92–2.29)
Excessive gestational weight gain 33 (6.4%) 21 (12.2%) 2.04 (1.10–3.75)
Low gestational weight gain 206 (39.9%) 46 (26.7%) 0.55 (0.37–0.82)
Monochorionicity 225 (43.6%) 87 (50.6%) 1.32 (0.92–1.90)

OR: odds ratio, CI: confidence interval, ANC: antenatal care, IVF: in-vitro fertilization