Fig 4. Hypothesized pathway for the maintenance of the ovarian phenotype in stage 12 sex reversed ZZf Pogona vitticeps.

Given the upregulation of these genes, it is likely that reactive oxygen species induce the phosphorylation, and subsequent activation and nuclear translocation of STAT4, likely mediated by PDGFB. Once in the nucleus, STAT4 is able to bind to promoter regions of known target genes, NR5A1, AMHR2 and EGR2 to regulate their expression and promote ovarian development.