Table 1. All genes, full gene names, functional categories and associations with either gene (ZWf) or temperature driven (ZZf) female development mentioned in the paper.
NA denotes a gene that was mentioned, but was not differentially expressed. Genes with an asterisk are those that have previously been implicated in thermosensitive sex determination cascades, either in Pogona vitticeps, or in another reptile species.
| Gene ID | Gene Name | Functional Category | Association |
|---|---|---|---|
| ADAD1 | Adenosine deaminase domain containing 1 [testis-specific] | Sex determination and differentiation (Male-specific) | ZWf/ZZf |
| ALDH1A2 | Retinal dehydrogenase 2 | Sex determination and differentiation (Male-specific) | ZWf |
| AMH | Anti-Müllerian hormone | Sex determination and differentiation | NA |
| AMHR2 | Anti-Müllerian hormone receptor 2 | Sex determination and differentiation | ZZf |
| ATF5 | Activating transcription factor 5 | Stress response | ZZf |
| ATP2B1 | ATPase plasma membrane Ca2+ transporting 1 | Calcium signalling | ZZf |
| ATP2B4 | ATPase plasma membrane Ca2+ transporting 4 | Calcium signalling | ZZf |
| BMP7 | Bone morphogenetic protein 7 | Sex determination and differentiation | ZZf |
| C2CD2 | C2 calcium-dependent domain containing 2 | Calcium signalling | ZZf |
| C2CD2L | C2 calcium-dependent domain containing 2 like | Calcium signalling | ZZf |
| CACNB3 | Calcium voltage-gated channel auxiliary subunit beta 3 | Calcium signalling | ZZf |
| CALM1 | Calmodulin 1 | Calcium signalling | ZWf/ZZf |
| CALR | Calreticulin | Calcium signalling | ZZf |
| CAMKK1 | Calcium/calmodulin dependent protein kinase kinase 1 | Calcium signalling | ZZf |
| CHMP1A | Chromatin modifying protein 1A | Chromatin remodelling | ZWf |
| CIRBP* | Cold-inducible binding protein | Temperature-sensing | ZZf |
| CLK4* | CDC like kinase 4 | Temperature-sensing | ZZf |
| CRH | Corticotropin releasing hormone/factor | Stress response | ZWf |
| CYP17A1 | Cytochrome P450 17A1 | Sex determination and differentiation (Female-Specific) | ZWf/ZZf |
| CYP19A1 | Aromatase | Sex determination and differentiation (Female-Specific) | ZWf/ZZf |
| DDIT4 | DNA damage inducible transcript 4 | DNA damage repair | ZZf |
| DLL3 | Delta like canonical Notch ligand 3 | Sex determination and differentiation (Male-specific) | ZWf/ZZf |
| DLL4 | Delta like canonical Notch ligand 4 | Sex determination and differentiation (Male-specific) | ZWf/ZZf |
| DMRT1 | Doublesex and mab-3 related transcription factor 1 | Sex determination and differentiation (Male-specific) | NA |
| EGR1 | Early growth response 1 | Sex determination and differentiation | ZZf |
| EIF1 | Eukaryotic translation initiation factor 1 | Translation initiation | ZZf |
| EIF4A2 | Eukaryotic translation initiation factor 4A2 | Translation initiation | ZZf |
| ENDOD1 | Endonuclease domain containing 1 | DNA damage repair | ZZf |
| ESR2 | Estrogen receptor 2 | Sex determination and differentiation (Female-Specific) | ZWf |
| ESRRG | Estrogen related receptor gamma | Sex determination and differentiation (Female-Specific) | ZZf |
| FIGLA | Folliculogeneisis specific basic helix-loop-helix | Sex determination and differentiation (Female-Specific) | ZWf/ZZf |
| FOXL2 | Forkhead box L2 | Sex determination and differentiation (Female-Specific) | ZWf/ZZf |
| FOXO3 | Forkhead box O3 | Redox regulation | ZZf |
| FZD1 | Frizzled class receptor 1 | Sex determination and differentiation | ZZf |
| GADD45G | Growth arrest and DNA damage inducible gamma | Sex determination and differentiation | ZWf |
| GATA6 | GATA binding factor 6 | Sex determination and differentiation | ZWf |
| GCA | Grancalcin | Calcium signalling | ZWf |
| GLRX | Glutaredoxin | Redox regulation | ZZf |
| GPX1 | Glutathione peroxidase | Redox regulation | ZZf |
| HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | DNA damage repair | ZZf |
| HNRNPUL1 | Heterogeneous nuclear ribonucleoprotein U like 1 | Splicing | ZWf/ZZf |
| HSD17B3 | Hydroxysteroid 17-beta dehydrogenase 3 | Sex determination and differentiation | ZZf |
| HSP40 | DnaJ heat shock protein family (hsp40) member B1 | Temperature-sensing | ZZf |
| HSP90AB1 | Heat shock protein 90 alpha family class B member 1 | Temperature-sensing | ZWf/ZZf |
| HSPA4 | Heat shock protein family A (Hsp70) member 4 | Temperature-sensing | ZWf/ZZf |
| HSPB1 | Heat shock protein family B (Small) member 1 | Temperature-sensing | ZWf/ZZf |
| HSPB11 | Heat shock protein family B (Small) member 11 | Temperature-sensing | ZWf/ZZf |
| HSPD1 | Heat shock protein family D (Hsp60) member 1 | Temperature-sensing | ZWf/ZZf |
| HSPH1 | Heat shock protein family H (Hsp110) member 1 | Temperature-sensing | ZWf/ZZf |
| IKBKG/NEMO | NF-κB essential modulator | NF-kB pathway | ZWf |
| JAG2 | Jagged 2 | Sex determination and differentiation | ZWf |
| JARID2* | Jumonji and AT-rich interaction domain containing 2 | Chromatin remodelling | ZZf |
| KCNN1 | Small conductance calcium-activated potassium channel protein 1 | Calcium signalling | ZZf |
| KCTD1 | Potassium channel tetramerization domain containing 1 | Sex determination and differentiation (Male-specific) | ZZf |
| KDM1A | Lysine demethylase 1A | Chromatin remodelling | ZWf/ZZf |
| KDM2B | Lysine demethylase 2B | Chromatin remodelling | ZWf/ZZf |
| KDM3B | Lysine demethylase 3B | Chromatin remodelling | ZWf/ZZf |
| KDM5B | Lysine demethylase 5B | Chromatin remodelling | ZWf/ZZf |
| KDM6B* | Lysine demethylase 6B | Chromatin remodelling | ZZf |
| LHX9 | LIM homeobox 9 | DNA damage repair | ZWf |
| LIG4 | DNA ligase 4 | DNA damage repair | ZZf |
| MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Stress response | ZWf/ZZf |
| MAPK1 | Mitogen-activated protein kinase 1 | Stress response | ZWf/ZZf |
| MAPK9 | Mitogen-activated protein kinase 9 | Stress response | ZWf/ZZf |
| MCU | Mitochondrial calcium uniporter | Calcium signalling | ZZf |
| MGST1 | Microsomal glutathione S-transferase 1 | Redox regulation | ZZf |
| NANOS1 | Nanos C2HC-type zinc finger 1 | Sex determination and differentiation (Female-Specific) | ZWf |
| NCOA4 | Nuclear receptor coactivator 4 | Sex determination and differentiation | ZZf |
| NEIL3 | Nei like DNA glycosylase 3 | DNA damage repair | ZZf |
| NR5A1 | Nuclear receptor subfamily 5 group A member 1 | Sex determination and differentiation | ZZf |
| NRF2 | Nuclear factor, erythroid 2 like 2 | Redox regulation | NA |
| PCGF1 | Polycomb group ring finger 1 | Chromatin remodelling | ZZf |
| PCGF2/Mel18 | Polycomb group ring finger 2 | Chromatin remodelling | ZWf |
| PCGF6 | Polycomb group ring finger 6 | Chromatin remodelling | ZZf |
| PCYOX1L | Prenylcysteine oxidate 1 like | Redox regulation | ZZf |
| PDGFB | Platelet derived growth factor subunit B, paralog of mammalian PDGFA | Sex determination and differentiation | ZZf |
| PGR | Progesterone receptor | Sex determination and differentiation (Female-Specific) | ZWf |
| PLCB1 | Phospholipase C Beta 1 | Calcium signalling | ZZf |
| PLCL2 | Phospholipase C like 2 | Calcium signalling | ZZf |
| POMC | Proopiomelanocortin | Stress response | NA |
| PRDX3 | Peroiredoxin 3 | Redox regulation | ZZf |
| PRKCI | Protein kinase C iota | NF-kB pathway | ZWf |
| RSPO1 | R-spondin 1 | Sex determination and differentiation (Female-Specific) | ZWf/ZZf |
| S100Z | S100 calcium binding protein Z | Calcium signalling | ZZf |
| SFRP2 | Secreted frizzled related protein 2 | Sex determination and differentiation (Male-specific) | ZZf |
| SOX4 | SRY-box transcription factor 4 | Sex determination and differentiation (Male-specific) | ZWf |
| SOX9 | Sry-box 9 | Sex determination and differentiation (Male-specific) | NA |
| SQOR | Sulfide quinone oxidoreductase | Redox regulation | ZZf |
| SRD5A2 | Steroid 5 alpha reductase 2 | Sex determination and differentiation | ZWf |
| STAT1 | Signal transducer and activator of transcription 1 | Stress response | ZWf |
| STAT4 | Signal transducer and activator of transcription 4 | Stress response | ZZf |
| STRA8 | Stimulated by retinoic acid 8 | Sex determination and differentiation | ZWf/ZZf |
| TERF2IP | Telomeric repeat-binding factor 2-interacting protein 1 | NF-kB pathway | ZWf |
| TGFBR3L | Transforming growth factor beta receptor 3-like, paralog of mammalian TGFBR3 | Sex determination and differentiation | ZZf |
| TMEM38B/TRICB | Trimeric intracellular cation channel type B | Calcium signalling | ZZf |
| TRPC4 | Transient receptor potential cation channel subfamily C member 4 | Temperature-sensing | ZZf |
| TRPV2* | Transient receptor potential cation channel subfamily V member 2 | Temperature-sensing | ZZf |
| TXNDC11 | Thioredoxin domain containing 11 | Redox regulation | ZZf |
| UBE2J1 | Ubiquitin-conjugating enzyme E2 J1 | Sex determination and differentiation | ZWf/ZZf |
| UCP2 | Oxidative stress responsive-gene uncoupling protein-2 | Redox regulation | ZZf |
| WNT5a | Wnt family member 5a | Sex determination and differentiation | ZZf |