Table 1.
Renal function, hemodynamic and biochemical parameters evaluated in rats after 90 days of a bilateral 45 min ischemia/reperfusion insult (IRI) on day 30.
| IRI | VDD+IRI | VDD+IRI+R | |
|---|---|---|---|
| CIn (mL/min/100 g BW) | 0.47 ± 0.02 | 0.46 ± 0.03 | 0.57 ± 0.02cf |
| PUr (mg/dL) | 44.10 ± 2.46 | 54.54 ± 2.82c | 47.45 ± 1.77f |
| MAP (mmHg) | 124.9 ± 2.56 | 142.0 ± 3.73a | 122.0 ± 2.56d |
| RBF (mL/min) | 7.90 ± 0.43 | 6.08 ± 0.03c | 8.80 ± 0.49e |
| RVR (mmHg/min) | 16.01 ± 1.07 | 22.37 ± 0.38a | 13.97 ± 0.85d |
| PAldo (pg/mL) | 2, 172±328.2 | 3, 612±662.4c | 1, 753±167.4e |
| Proteinuria (mg/24 h) | 10.14 ± 0.64 | 11.99 ± 0.83 | 9.13 ± 0.74f |
| P25(OH)D (ng/mL) | 42.62 ± 2.28 | <0.780a | 42.89 ± 2.58d |
| PPTH (pg/mL) | 806.5 ± 89.2 | 1, 378±215.4c | 778.4 ± 135.4f |
| PFGF−23 (pg/mL) | 356.4 ± 37.5 | 566.1 ± 26.2b | 653.0 ± 62.1a |
| FECa (%) | 0.65 ± 0.10 | 0.64 ± 0.12 | 0.54 ± 0.05 |
| FEP (%) | 8.89 ± 0.90 | 15.97 ± 1.01b | 12.61 ± 1.39c |
VDD, vitamin D deficiency; R, vitamin D replacement. Diet protocol: IRI, standard diet for 120 days; VDD+IRI, vitamin D-free diet for 120 days; and VDD+IRI+R, vitamin D-free diet in the first 30 days and standard diet in the last 90 days. CIn, inulin clearance; BW, body weight; PUr, plasma urea concentration; MAP, mean arterial pressure; RBF, renal blood flow; RVR, renal vascular resistance; PAldo, plasma aldosterone concentration; P25(OH)D, plasma 25 hydroxyvitamin D concentration; PPTH, plasma parathormone concentration; PFGF−23, plasma fibroblast growth factor 23 concentration; FECa, fractional excretion of calcium; FEP, fractional excretion of phosphorus. Values are mean ± SEM. ap < 0.001, bp < 0.01, cp < 0.05 vs. IRI; dp < 0.001, ep < 0.01, fp < 0.05 vs. VDD+IRI.