Table 1.
Associations between specific underlying conditions and mortality among all COVID-19 confirmed cases within the study subset (n=19,789) a.
| Risk factor | Alive (n= 18313) | Died (n=1476) | Unadjusted OR (95% CI) | Adjusted OR for age1 (95% CI) | Adjusted OR2 (95% CI) |
|---|---|---|---|---|---|
|
Gender Male Female (reference) |
7882 10431 |
754 (8.73%) 722 (6.47%) |
1.38 (1.24, 1.54) |
1.56 (1.38, 1.77)*** |
1.66 (1.43, 1.94)*** |
|
Chronic heart disease Yes No |
2055 16258 |
645 (23.89%) 831 (4.86%) |
6.14 (5.49, 6.87) |
1.63 (1.43, 1.85)*** |
1.28 (1.09, 1.50)** |
|
Chronic neurological condition Yes No |
713 17600 |
511 (41.75%) 965 (5.20%) |
13.07 (11.47, 14.90) |
2.64 (2.28, 3.07)*** |
1.41 (1.17, 1.69)** |
|
Chronic respiratory disease Yes No |
1824 16489 |
259 (12.43%) 1217 (6.87%) |
1.92 (1.67, 2.22) |
1.20 (1.02, 1.42)* |
1.09 (0.89, 1.33) |
|
Chronic kidney disease Yes No |
384 17929 |
174 (31.18%) 1302 (6.77%) |
6.24 (5.17, 7.53) |
1.99 (1.60, 2.47)*** |
1.74 (1.35, 2.24)*** |
|
Chronic liver disease Yes No |
134 18179 |
28 (17.28%) 1448 (7.38%) |
2.63 (1.74, 3.96) |
1.44 (0.90, 2.31) |
1.32 (0.80, 2.19) |
|
Asthma (requiring medication) Yes No |
438 17875 |
29 (6.21%) 1447 (7.49%) |
0.82 (0.56, 1.20) |
0.82 (0.53, 1.26) |
0.82 (0.50, 1.35) |
|
Immunodeficiency incl. HIV Yes No |
364 17949 |
38 (9.45%) 1438 (7.42%) |
1.30 (0.93, 1.83) |
1.25 (0.85, 1.85) |
0.87 (0.56, 1.35) |
|
Diabetes Yes No |
999 17314 |
225 (18.38%) 1251 (6.74%) |
3.12 (2.67, 3.64) |
1.40 (1.17, 1.67)** |
1.08 (0.87, 1.33) |
|
BMI ≥40kg/m2 Yes No |
267 18046 |
31 (10.40%) 1445 (7.41%) |
1.45 (1.00, 2.11) |
2.48 (1.59, 3.87)** |
2.89 (1.80, 4.64)*** |
|
Cancer / malignancy Yes No |
514 17799 |
233 (31.19%) 1243 (6.53%) |
6.49 (5.50, 7.66) |
2.58 (2.13, 3.13)*** |
2.77 (2.21, 3.47)*** |
|
Other comorbidity Yes No |
3282 15031 |
924 (21.97%) 552 (3.54%) |
7.67 (6.85, 8.58) |
3.23 (2.84, 3.67)*** |
2.24 (1.91, 2.63)*** |
|
Comorbidity unknown$ Yes No |
1496 16817 |
93 (5.85%) 1383 (7.60%) |
0.76 (0.61, 0.94) |
0.27 (0.21, 0.34)*** | 0.40 (0.29, 0.55)*** |
|
Residential care facility Yes No |
785 17528 |
813 (50.88%) 663 (3.64%) |
27.38 (24.16, 31.03) |
4.54 (3.93, 5.24)*** |
12.76 (10.31, 15.78)*** |
aAge is modeled as a polynomial in the model and therefore odds ratios are not directly interpretable
1Adjusted OR, adjusted for age (linear, quadratic, cubic)
2Adjusted OR, adjusted for age (linear, quadratic, cubic), chronic heart disease, chronic neurological disease, chronic respiratory disease, chronic kidney disease, chronic liver disease, asthma (requiring meds), immunodeficiency, diabetes, BMI ≥40, cancer, other comorbidity, unknown comorbidity, community health office, residential care facility and route of transmission.
$Where an underlying clinical condition was indicated but none of the conditions listed (and pregnancy) were reported. Odds ratios (OR), 95% confidence intervals (95%CI). P-value for overall association (Wald χ2) *p<0.05; ** p<0.001; *** p<0.0001.