Table 3.
Associations between underlying conditions and ICU admission among those who were hospitalised from COVID-19 within the study subset (n=2,811)a.
| Risk factor | No ICU admission but hospitalised (n=2373) | ICU admission (n=438) | Unadjusted OR (95% CI) | Adjusted OR for age1 (95% CI) | Adjusted OR2 (95% CI) |
|---|---|---|---|---|---|
|
Gender Male Female (reference) |
1314 1059 |
302 (18.69%) 136 (11.38%) |
1.79 (1.44, 2.23) |
1.61 (1.28, 2.02)*** |
1.53 (1.19, 1.97)** |
|
Chronic Heart Disease Yes No |
775 1598 |
216 (21.80%) 222 (12.20%) |
2.01 (1.63, 2.47) |
2.90 (2.29, 3.68)*** |
2.48 (1.90, 3.24)*** |
|
Chronic Neurological condition Yes No |
338 2035 |
20 (5.59%) 418 (17.04%) |
0.29 (0.18, 0.46) |
0.38 (0.24, 0.62)*** |
0.35 (0.21, 0.60)** |
|
Chronic respiratory disease Yes No |
451 1922 |
107 (19.18%) 331 (14.69%) |
1.38 (1.08, 1.75) |
1.47 (1.14, 1.90)* |
0.99 (0.73, 1.34) |
|
Chronic Kidney Disease Yes No |
237 2136 |
40 (14.44%) 398 (15.71%) |
0.91 (0.64, 1.29) |
1.10 (0.76, 1.60) |
1.00 (0.66, 1.52) |
|
Chronic Liver Disease Yes No |
54 2319 |
14 (20.59%) 424 (15.46%) |
1.42 (0.78, 2.58) |
1.10 (0.59, 2.04) |
0.86 (0.43, 1.72) |
|
Asthma (requiring medication) Yes No |
108 2265 |
50 (31.65%) 388 (14.62%) |
2.70 (1.90, 3.84) |
2.63 (1.80, 3.84)*** |
2.31 (1.47, 3.63)** |
|
Immunodeficiency incl. HIV Yes No |
87 2286 |
26 (23.01%) 412 (15.27%) |
1.66 (1.06, 2.60) |
1.38 (0.86, 2.20) |
1.46 (0.88, 2.43) |
|
Diabetes Yes No |
347 2026 |
111 (24.24%) 327 (13.90%) |
1.98 (1.55, 2.53) |
1.94 (1.50, 2.52)*** |
1.27 (0.93, 1.72) |
|
BMI ≥40kg/m2 Yes No |
52 2321 |
82 (61.19%) 356 (13.30%) |
10.28 (7.14, 14.81) |
7.91 (5.39, 11.59)*** |
7.53 (4.94, 11.48)*** |
|
Cancer / malignancy Yes No |
301 2072 |
50 (14.25%) 388 (15.77%) |
0.89 (0.65, 1.22) |
0.91 (0.65, 1.27) |
0.90 (0.62, 1.30) |
|
Other comorbidity Yes No |
894 1479 |
210 (19.01%) 228 (13.36%) |
1.52 (1.24, 1,87) |
1.81 (1.45, 2.25)*** |
1.75 (1.37, 2.24)*** |
|
Comorbidity unknown$ Yes No |
155 2218 |
4 (2.52%) 434 (16.37%) |
0.13 (0.05, 0.36) |
0.17 (0.06, 0.46)** |
0.38 (0.13, 1.06) |
|
Residential care facility Yes No |
224 2149 |
9 (3.86%) 429 (16.64%) |
0.20 (0.10, 0.40) |
0.35 (0.17, 0.69)* |
0.58 (0.27, 1.28) |
aAge is modeled as a polynomial in the model and therefore odds ratios are not directly interpretable
1Adjusted OR, adjusted for age (linear, quadratic, cubic)
2Adjusted OR, adjusted for age (linear, quadratic, cubic), chronic heart disease, chronic neurological disease, chronic respiratory disease, chronic kidney disease, chronic liver disease, asthma (requiring meds), immunodeficiency, diabetes, BMI ≥40, cancer, other comorbidity, unknown comorbidity, community health office, residential care facility and route of transmission.
$Where an underlying clinical condition was indicated but none of the conditions listed (and pregnancy) were reported. Odds ratios (OR), 95% confidence intervals (95%CI). P-value for overall association (Wald χ2) *p<0.05; ** p<0.001; *** p<0.0001.