TABLE 3.
Total Distribution Volumes Derived with 1TC Model for 18F-SynVesT-1 and 11C-UCB-J Under Baseline and Levetiracetam Blocking Conditions
|
18F-SynVesT-1 (n = 4) |
11C-UCB-J (n = 4) |
|||
| Region | Baseline | Blocking | Baseline | Blocking |
| Putamen | 18.7 (18%) | 5.1 (14%) | 20.5 (14%) | 7.2 (10%) |
| Insular cortex | 18.4 (21%) | 4.9 (13%) | 19.6 (15%) | 6.9 (11%) |
| Temporal cortex | 18.8 (20%) | 4.6 (8%) | 20.4 (15%) | 6.8 (7%) |
| Parietal cortex | 18.1 (21%) | 4.3 (6%) | 20.1 (15%) | 6.6 (7%) |
| Amygdala | 17.4 (13%) | 4.7 (12%) | 19.1 (13%) | 7.0 (13%) |
| Occipital cortex | 17.7 (24%) | 4.2 (6%) | 19.5 (20%) | 6.3 (4%) |
| Anterior cingulate cortex | 17.6 (21%) | 4.8 (16%) | 19.0 (20%) | 7.0 (15%) |
| Frontal cortex | 17.1 (18%) | 4.3 (8%) | 18.8 (12%) | 6.4 (8%) |
| Caudate nucleus | 15.9 (15%) | 4.3 (12%) | 17.6 (14%) | 6.3 (12%) |
| Posterior cingulate cortex | 15.9 (32%) | 4.0 (9%) | 16.9 (28%) | 5.9 (19%) |
| Thalamus | 13.3 (14%) | 4.0 (13%) | 14.5 (12%) | 5.7 (6%) |
| Cerebellum | 13.0 (17%) | 3.6 (12%) | 13.7 (13%) | 5.2 (5%) |
| Hippocampus | 13.2 (13%) | 3.8 (11%) | 14.1 (10%) | 5.5 (10%) |
| Globus pallidus | 11.9 (27%) | 4.2 (14%) | 12.5 (18%) | 5.6 (6%) |
| CS | 3.6 (13%) | 2.4 (6%) | 4.5 (10%) | 3.4 (4%) |
Data in parentheses represent %COV (percentage coefficient of variation [intersubject variability]).