Figure 5.

A plethora of water molecules mediate interactions between CV38-142 and SARS-CoV-2 and SARS-CoV RBD

SARS-CoV-2 RBD is in white, SARS-CoV RBD in pale blue, CV38-142 heavy chain in forest green and light chain in wheat. Corresponding residues that differ between SARS-CoV-2 and SARS-CoV are labeled with asterisks (^∗). Dashed lines (black) represent hydrogen bonds. Amino acid residues as well as the glycans involved in the water-mediated interactions are shown in sticks. Yellow spheres indicate water molecules in the same location in the structures of the CV38-142 Fab + SARS-CoV-2 RBD + COVA1-16 Fab complex (A) and the CV38-142 Fab + SARS-CoV RBD (B). Grey spheres indicate unique water molecules in each complex structure.

See also Figure S4.