Table 1.

The nuclear shuttle protein (NSP) function and amino acid identity between COVID-19 and bat-SL-CoVZXC21 and SARS [10]. Keys: ACIB, Amino acid identity; btw, between; Fm, formulation.

NSPs and other parts of coronaviruses	Putative function	Amino acid position	Putative cleave site	AC identity btw COVID-19 & bat-SL-CoVZXC21	AC identity btw COVID-19 & SARS
NSP1	suppress antiviral host response	M1 – G180	LNGG'AYTR	96	84
NSP2	unknown	A181 – G818	LKGG'APTK	96	68
NSP3	putative PL-pro domain	A819 – G2763	LKGG'KIVN	93	76
NSP4	complex with nsp3 and 6: DMV Fm	K2764 – Q3263	AVLQ'SGFR	96	80
NSP5	3CL-pro domain	S3264 – Q3569	VTFQ'SAVK	99	96
NSP6	complex with nsp3 and 4: DMV Fm	S3570 – Q3859	ATVQ'SKMS	98	88
NSP7	complex with nsp8: primase	S3860 – Q3942	ATLQ'AIAS	99	99
NSP8	complex with nsp7: primase	A3943 – Q4140	VKLQ'NNEL	96	97
NSP9	RNA/DNA binding activity	N4141 – Q4253	VRLQ'AGNA	96	97
NSP10	complex with nsp14: replication	A4254 – Q4392	PMLQ'SADA	98	97
NSP11	short peptide at the end of orf1a	S4393 – V4405	end of orf1a	85	85
NSP12	RNA-dependent RNA polymerase	S4393 – Q5324	TVLQ'AVGA	96	96
NSP13	helicase	A5325 – Q5925	ATLQ'AENV	99	100
NSP14	ExoN: 3′–5′ exonuclease	A5926 – Q6452	TRLQ'SLEN	95	95
NSP15	XendoU: poly(U)-specific endoribonuclease	A5926 – Q6452	PKLQ'SSQA	88	89
NSP16	2′-O-MT: 2′-O-ribose methyltransferase	S6799 – N7096	end of orf1b	98	93
Spike	Host cell attachment and entry	-	-	80	76
Orf3a		-	-	92	72
Orf3b		-	-	32	32
Envelope	protection	-	-	100	95
Membrane	fusion	-	-	99	91
Orf6		-	-	94	69
Orf7a		-	-	89	85
Orf7b		-	-	93	81
Orf8a/8b		-	-	94	40
Nucleoprotein	Viral genome and proteins	-	-	94	94
Orf9b		-	-	73	73
Envelope	protection	-	-	100	95
Membrane	fusion	-	-	99	91
Orf6		-	-	94	69
Orf7a		-	-	89	85
Orf7b		-	-	93	81
Orf8a/8b		-	-	94	40
Nucleoprotein	Viral genome and proteins	-	-	94	94
Orf9b		-	-	73	73