Skip to main content
. 2021 Apr 1;9:660853. doi: 10.3389/fcell.2021.660853

FIGURE 2.

FIGURE 2

Feedbacks between AR and ncRNAs. (A) AR binds to the promoter region of lncRNA ARLNC1 and induces its expression. ARLNC1 binds to and stabilizes AR mRNA, which increases AR expression and further activates the transcription of itself, ARLNC1, forming a positive feedback regulation loop. (B) AR binds to the promoter region of miR-31 and suppresses its expression. MiR-31 induces AR mRNA degradation via targeting the coding region of AR mRNA, thus forming a negative feedback regulation loop.