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. 2021 Apr 1;9:660853. doi: 10.3389/fcell.2021.660853

FIGURE 3.

FIGURE 3

LncRNAs bind to steroid receptors and regulate their activities. (A) Principal functional domains of steroid receptors. The steroid receptors have N-terminal regulatory domain, central DNA binding domain, ligand-binding domain, and C-terminal extension. (B) LncRNAs containing steroid receptor responsive element (SRE) mimic RNA sequence, such as GAS5, block the binding of steroid receptors to SRE DNA sequence, and suppress steroid receptors’ transcriptional activity. (C) LncRNAs containing short, pyrimidine-rich RNA motif, such as SRA and SLNCR1, bind to steroid receptors at N-terminal, regulatory domain, and increase steroid receptors’ transcriptional activity.