TABLE 1.
MiRNAs targeting AR mRNA.
| MiRNAs (References) | Expression in PCa | Target region of AR mRNA | Cancer types | Function in cancer cells |
| miR-124 (Shi et al., 2013, 2015; Xiong et al., 2017) | ↓ | 3′UTR | PCa, bladder cancer | Inhibits cell growth and increases apoptosis |
| miR-135b (Ostling et al., 2011; Aakula et al., 2015; Bao S. X. et al., 2020) | ↓ | 3′UTR | PCa, hepatocellular carcinoma (HCC), breast cancer | Inhibits cell growth |
| miR-181c-5p (Wu et al., 2019) | – | 3′UTR | PCa | Increases ENZ sensitivity of PCa cells and represses cell invasion |
| miR-185 (Ostling et al., 2011; Qu et al., 2013; Liu C. et al., 2015; Kalinina et al., 2020) | ↓ | 3′UTR | PCa, breast cancer | Suppresses cell growth, migration, invasion, and tumorigenicity |
| miR-193a-3p (Kumar et al., 2016; Liu et al., 2017) | ↓ | Coding region | PCa | Suppresses cell growth |
| miR-197-3p (Fletcher et al., 2019; Huang et al., 2020) | ↓ | 3′UTR | PCa | Inhibits cell growth and colony formation |
| miR-205 (Boll et al., 2013; Hagman et al., 2013; Coarfa et al., 2016; Kalinina et al., 2020) | ↓ | 3′UTR | PCa, breast cancer | Suppresses cell growth, migration, and invasion |
| miR-297 (Ostling et al., 2011; Fang et al., 2016) | ↓ | 3′UTR | PCa | Suppresses cell growth |
| miR-299-3p (Ostling et al., 2011; Ganapathy et al., 2020) | ↓ | 3′UTR | PCa | Suppresses cell growth, migration, induces cell cycle arrest, and apoptosis |
| miR-30b-3p (Kao et al., 2014; Kumar et al., 2016) | ↓ | 3′UTR | PCa | Suppresses EMT phenotypes and inhibits cell migration and invasion |
| miR-31 (Lin et al., 2013; Coarfa et al., 2016; Wang et al., 2016) | ↓ | Coding region | PCa | Suppresses cell growth, migration and invasiveness |
| miR-320a (Okato et al., 2016; Sato et al., 2016; Lieb et al., 2018) | ↓ | 3′UTR | PCa | Suppresses cell growth, migration and invasiveness |
| miR-320b (Hsieh et al., 2013; Lieb et al., 2018; Dai et al., 2019) | ↓ | 3′UTR | PCa | Suppresses cell growth |
| miR-346 (Fletcher et al., 2019; Lin et al., 2020) | ↑ | 3′UTR | PCa | Promotes cell growth and invasion |
| miR-34a (Liu et al., 2011; Ostling et al., 2011; Kashat et al., 2012; Leite et al., 2015) | ↓ | 3′UTR | PCa | Inhibits prostate cancer stem cell regeneration and metastasis |
| miR-34c (Hagman et al., 2010; Ostling et al., 2011; Walter et al., 2013; Fang et al., 2016) | ↓ | 3′UTR | PCa | Suppresses cell growth |
| miR-361-3p (Fletcher et al., 2019; Liu B. et al., 2020) | ↓ | 3′UTR | PCa | Suppresses cell growth and increases ENZ sensitivity of PCa cells |
| miR-371-3p (Ostling et al., 2011; Leite et al., 2015; Kumar et al., 2016) | ↓ | Coding region, 3′UTR | PCa | Suppresses cell growth |
| miR-421 (Ostling et al., 2011; Meng et al., 2016) | ↓ | 3′UTR | PCa | Suppresses cell growth, induces cell cycle arrest, reduces glycolysis, and inhibits migration |
| miR-449a (Ostling et al., 2011; Zheng et al., 2015; Chen W. et al., 2017; Guo et al., 2018) | ↓ | 3′UTR | PCa, bladder cancer | Suppresses cell growth, invasion, and angiogenesis |
| miR-449b (Ostling et al., 2011; Mortensen et al., 2014) | ↑ | 3′UTR | PCa | Suppresses cell growth |
| miR-488∗ (Sikand et al., 2011; Ebron and Shukla, 2016) | - | 3′UTR | PCa | Suppresses cell growth, increases apoptosis |
| miR-541-3p (Kumar et al., 2016; He et al., 2021) | ↓ | 3′UTR | PCa | Suppresses cell growth and enhances the radiosensitivity of PCa cells |
| miR-634 (Ostling et al., 2011; Kumar et al., 2016) | – | 3′UTR | PCa | Suppresses cell growth |
| miR-646 (Kumar et al., 2016) | – | Coding region 3′UTR | PCa | Suppresses cell growth |
| miR-654-5p (Ostling et al., 2011; Kumar et al., 2016) | – | 3′UTR | PCa | Suppresses cell growth |
| miR-92a-2-5p (Liu G. et al., 2020) | – | 3′UTR | HCC | Increases liver cancer cell invasion |
| miR-9-5p (Ostling et al., 2011; Kumar et al., 2016; Moazzeni et al., 2017; Bandini et al., 2020) | – | 3′UTR | PCa, breast cancer | Suppresses cell growth |