Table 1.
Epidemiology of Tissue Microarray Cohort
| Diagnosis | WHO grade | Cases | Gender (F/M) | Mean age (range) | Primary/recurrent | IDH mutant/IDH wild type | MGMT methylated/unmethylated | ATRX loss/retention | LOH1p19q / retention |
|---|---|---|---|---|---|---|---|---|---|
| Oligodendroglioma | II | 61 | 28/33 | 45.1 (17-74) | 56/5 | 61/0 | 9/0 | 1/60 | 61/0 |
| Anaplastic oligodendroglioma | III | 32 | 14/18 | 46.7 (26-79) | 19/13 | 32/0 | 21/1 | 1/31 | 32/0 |
| Astrocytoma | II | 53 | 19/34 | 42.8 (5-70) | 45/8 | 36/17 | 4/7 | 33/20 | 0/9 |
| Anaplastic astrocytoma | III | 61 | 20/41 | 43.9 (10-76) | 38/23 | 35/26 | 2/8 | 34/27 | 0/5 |
| Glioblastoma | IV | 215 | 81/134 | 59.5 (10-88) | 179/36 | 20/195 | 57/84 | 25/190 | 0/2 |
| Gliosarcoma | IV | 48 | 18/30 | 59.8 (26-83) | 30/18 | 0/48 | 15/26 | 0/48 | ND |
| Pilocytic astrocytoma | I | 82 | 43/39 | 23.3 (2-78) | 67/15 | 0/82 | ND | 0/82 | ND |
| All tumors | 552 | 223/329 | 48.5 (2-88) | 434/118 | 184/368 | 108/126 | 94/376 | 93/16 |
Abbreviations: M, male; F, female; IDH, isocitrate dehydrogenase; ND, not determined; LOH, loss of heterozygosity; MGMT, O6-methylguanine DNA methyltransferase; ATRX, alpha thalassemia/mental retardation syndrome X-linked; WHO, World Health Organization.