. Author manuscript; available in PMC: 2021 Apr 15.

Published in final edited form as: Nat Neurosci. 2015 Jul 20;18(8):1183–1189. doi: 10.1038/nn.4067

Table 1.

Summary of unambiguously assigned tau modifications in wildtype mice.

Modification	Sites assigned	Previously reported sites^a	Residue conserved in human tau 441	Sites in the MBRD	Sites with alternate modifications
Arginine methylation	3	1 (0.33)^b	3 (1.0)	1 (0.33)	0 (0)
Lysine acetylation	14	6 (0.42)	14 (1.0)	10 (0.71)	12 (0.86)
Lysine Mono-methylation	1	1 (1.0)	1 (1.0)	1 (1.0)	1 (1.0)
Lysine Di-methylation	2	1 (0.5)	2 (1.0)	1 (0.5)	2 (1.0)
Lysine ubiquitination	15	4 (0.27)	15 (1.0)	11 (0.73)	11 (0.73)
Serine O-GlcNAcylation	1	1 (1.0)	1 (1.0)	0 (0)	1 (1.0)
Serine/threonine/tyrosine phosphorylation	27	27 (1.0)	24 (0.89)	2 (0.07)	1 (0.04)

Based on in vitro or in vivo experiments.

Numbers in parentheses indicate the proportion of total for each modification.