Table 1:

Viruses

Vector	Type	Capacity	Onset	Duration	Advantages	Disadvantages
Adeno	dsDNA	~8kb	Days	Weeks	High packaging capacity Transient Integrates into genome	High immune response BSL2
AAV	ssDNA	~5kb	Weeks	Years	Safe (BS1) Easy production Long lasting Low immune response Good penetration Anterograde or retrograde delivery	Limited packaging compacity Does not integrate into genome
Lentivirus	RNA	~8kb	Weeks	Years	High packaging capacity Integrates into genome Easy production Long lasting Low immune response	BSL2 Expression is spatially limited
Rabies Virus	RNA	~5kb	Days	Weeks	Rapid expression	BSL2 Cytotoxicity by 2 weeks
HSV-1	dsDNA	~30–50kb	Hours	8–10 days	Largest packaging capacity Neurotropic Transient	BSL2 More difficult to produce
LT-HSV-1	dsDNA	~30–50kb	Weeks	Indefinite	Largest packaging capacity Retrograde transfer properties Neurotropic Long lasting	BSL2 More difficult to produce

AAV: Adenoassociated Virus; HSV-1: Herpes Simplex Virus