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. Author manuscript; available in PMC: 2021 Apr 15.
Published in final edited form as: Nat Genet. 2020 Nov 30;52(12):1346–1354. doi: 10.1038/s41588-020-00740-8

Extended Data Fig. 6 |. Population concordance of heterozygosity (2pq) among variants prioritized by IMPACT compared to standard P+T.

Extended Data Fig. 6 |

a) Heterozygosity of variants from genome-wide EUR and EAS PrCa summary statistics in the top 5% of the lead IMPACT annotation for EUR PrCa. b) Heterozygosity of variants from genome-wide EUR and EAS PrCa summary statistics using standard P+T. c) Heterozygosity of variants from genome-wide EUR and EAS PrCa summary statistics in the bottom 95% of the lead IMPACT annotation for PrCa; mutually exclusive with SNPs in A). d) Meta-analysis of heterozygosity correlations between populations across 21 traits shared between EUR and EAS cohorts over 17 GWAS P value thresholds (with reference to the EUR GWAS).