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. Author manuscript; available in PMC: 2021 Apr 15.
Published in final edited form as: Nat Genet. 2020 Nov 30;52(12):1346–1354. doi: 10.1038/s41588-020-00740-8

Fig. 3 |. Trans-ancestry concordance of regulatory elements defined by IMPACT.

Fig. 3 |

a, Illustrative concept of concordance versus discordance of τ* between populations. Concordance implies a similar distribution of causal variants and effects captured by the same annotation. The implications of discordant τ* are not as straightforward. b, Common per-SNP heritability (τ*) estimate for sets of independent IMPACT annotations across 29 traits shared between EUR and EAS. Left: color indicates τ* significance (sig.; τ* greater than 0 at 5% FDR). Line of best fit through annotations significant in both populations (dark purple line, 95% CI in light purple). Black dotted line is the identity line, y = x. Right: color indicates association to one of five exemplary traits.