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. Author manuscript; available in PMC: 2021 Apr 15.
Published in final edited form as: Nat Genet. 2020 Nov 30;52(12):1346–1354. doi: 10.1038/s41588-020-00740-8

Fig. 4 |. Mechanism by which IMPACT prioritization of shared regulatory variants might improve trans-ancestry PRS performance.

Fig. 4 |

a, Estimated effect sizes of variants from genome-wide EUR and EAS height summary statistics in the top 5% of the lead IMPACT annotation for EUR height. Proportions of variants in each quadrant indicated in light blue. b, Estimated effect sizes from genome-wide EUR and EAS height summary statistics of variants in the bottom 95% of the same lead IMPACT annotation for height; mutually exclusive with SNPs in a. c, Meta-analysis of trans-ancestry marginal effect size correlations between populations across 21 traits shared between EUR and EAS cohorts over 17 GWAS P value thresholds (with reference to the EUR GWAS). Vertical bars indicate the 95% CI around the Pearson r estimate. d, Number of SNPs (log10 scale) at each P value threshold for each partition of the genome corresponding to c. Error bars indicate 1 s.d. above and below the mean.