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. Author manuscript; available in PMC: 2021 Apr 15.
Published in final edited form as: Adv Funct Mater. 2017 Jun 7;28(12):1700239. doi: 10.1002/adfm.201700239

Figure 11.

Figure 11.

Nanoparticle delivery across the BBB can be facilitated by temporarily disrupting the BBB using external stimuli. a) Applying a magnetic force externally allows the transport of magnetic nanoparticles into the brain. Reproduced with permission.[223] Copyright 2012, Elsevier. b) MRI-assisted ultrasound facilitates the delivery of gadolinium nanoparticles to the brain, and more gadolinium entered the brain at higher pressures. Reproduced with permission.[204] Copyright 2014, Elsevier. (c) Temporary disruption in the BBB due to injected magnetic nanoparticles and an applied external field which induces localized hyperthermia and is illustrated by the transport of Evans blue dye into the treated hemisphere of the brain. Reproduced with permission.[165] Copyright 2015, Elsevier.