Table 2.
Demographics and general clinical data of our population and the control group derived from Bjordal et al. [15]. Data are expressed as absolute values and percentage in brackets. COPD, chronic obstructive pulmonary disease; HNC, head and neck cancer; LP, laryngectomized population; NA, not available; RT, radiotherapy
| Overall population [121] | Control group [360] | p-value | LP group [64] | Other HNC [57] | p-value | ||
|---|---|---|---|---|---|---|---|
| Median age (range) | 67 (35–95) | 61 (22–91) | - | Subgroup analysis of our population [121] | 73.5 (44–95) | 64 (35–87) | - |
| Sex | 0.107 | ||||||
| Male | 91 (75.2) | 295 | 52 | 39 | |||
| Female | 30 (24.8) |
(81.9) 65 (18.1) |
(81.2) 12 (18.8) |
(68.4) 18 (31.6) |
0.103 | ||
| Positive smoking history | 83 (68.6) | NA | - | 47 (73.4) | 36 (63.2) | 0.224 | |
| Mean pack/years | 72.4 | NA | - | 63.23 | 79.53 | 0.196 | |
| COPD/asthma | 23 (19) | NA | - | 15 (23.4) | 8 (14) | 0.188 | |
| Site | 0.380 | - | |||||
|
Oral cavity Oropharynx Larynx Hypopharynx Nasopharynx |
34 (28.1) 12 (9.9) 63 (52) 5 (4.2) 7 (5.8) |
107 (29.7) 41 (11.3) 185 (51.3) 19 (5.2) 8 (2.5) |
- - 59 (92.2) 5 (7.8) - |
34 (59.6) 12 (21) 4 (7.1) 0 (0) 7 (12.3) |
|||
| History of previous RT | 98 (80.9) | 309 (85.8) | 0.201 | 56 (71.8) | 42 (49.1) | 0.053 | |