Scheme 3.
Synthesis of nucleoside phosphonodiphosphates. Reagents and conditions: (a) Imidazole, trioctylamine, PPh3, Aldrithiol™, DMF, 16 h, rt; (b) tributylammonium pyrophosphate, DMF, 16 h, rt; (c) Dowex® 50 (Na+ cycle), 45%.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.