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. 2021 Apr 16;89:132159. doi: 10.1016/j.tet.2021.132159

Scheme 4.

Scheme 4

Synthesis of prodrugs. Reagents and conditions: (a) Phenol, l-phenylalanine butyl ester, Et3N, pyridine, 15 min, 60 °C (b) PPh3, Aldrithiol™, pyridine, 16 h, 60 °C, 56%.