Table 1.

Key areas for clinical research on COVID-19 in pediatric populations.

Pathophysiology and natural history	• Characteristics of SARS-CoV-2 infection in neonates, children and adolescents.
	• Correlates of risk, progression, recovery and protection.
	• Studies of transmission to and from children, including household transmission, particularly in the elderly.
Viral diagnosis	• Development of rapid point-of-care diagnostics for children and methods for assessment of viral load and shedding of infectious virus.
	• Large-scale testing of pediatric patients to determine rates of infection and potential coinfection with other respiratory viruses.
	• Multiyear assessments of recurrent infection in infants/children.
Detection of antibodies	• Development of rapid point-of-care tests for detection of SARS-CoV-2 Ab.
	• Methodology for detecting and quantitating neutralizing Ab.
	• Long-term studies of durability of antibody response.
Framework for antiviral development	• Knowledge base for information about candidates in development.
	• Pediatric engagement early in development for input regarding pediatric needs and optimal planning for pediatric studies.
	• Mechanism for input regarding risk: benefit assessment.
Evaluation of vaccine candidates	• Assessment of developmental effects on vaccine response.
	• Evaluation of risk for enhancing responses to vaccine candidates.
	• Pediatric engagement early in development for input regarding pediatric needs and optimal planning for pediatric studies.
	• Mechanism for input regarding risk: potential benefit.