Table 3.
Association of dysnatremia with AKI development
| Overall | Normonatremia | Hyponatremia | Hypernatremia | |
|---|---|---|---|---|
| No. of patients | 56,961 | 44,178 | 8803 | 3980 |
| Person-years | 1541 | 1167 | 269 | 106 |
| Time to AKI, median (IQR), days | – | – | 8.0 (10.0) | 7.0 (8.0) |
| Kidney outcome | ||||
| AKI (N, %) | 1450 (2.5) | 864 (2.0) | 381 (4.3) | 205 (5.2) |
| AKI per 1000 person-year | 940.9 | 740.4 | 1416.4 | 1934.0 |
| Cause-specific hazard model | ||||
| HR (95% CI | – | 1.00 (Reference) |
1.98 (1.76, 2.24) p < 0.001 |
2.69 (2.31, 3.13) p < 0.001 |
| HR (95% CI)* | – | 1.00 (Reference) |
1.87 (1.61, 2.16) p < 0.001 |
1.67 (1.41, 1.98) p < 0.001 |
*Adjusted for: age, sex, comorbidities, Na value at hospital admission, eGFR at baseline