Table 4.
Association between Na variability (CV) and AKI development
| No. of events (%) | Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | p value for trend | OR (95% CI) | p value for trend | OR (95% CI) | p value for trend | ||
|
Q1 CV ≤ 0.71 |
209 (1.4) | 1.00 (Reference) | < 0.001 | 1.00 (Reference) | < 0.001 | 1.00 (Reference) | < 0.001 |
|
Q2 0.71 < CV ≤ 1.25 |
289 (2.1) |
1.45 (121, 1.73) p < 0.001 |
1.25 (1.04, 1.50) p = 0.017 |
1.16 (0.97, 1.40) p = 0.115 |
|||
|
Q3 1.25 < CV ≤ 1.94 |
418 (2.9) |
2.08 (1.77, 2.47) p < 0.001 |
1.66 (1.40, 1.97) p < 0.001 |
1.41 (1.18, 1.70) p < 0.001 |
|||
|
Q4 CV > 1.94 |
534 (3.8) |
2.70 (2.30, 3.18) p < 0.001 |
2.12 (1.79, 2.51) p < 0.001 |
1.53 (1.24, 1.91) p < 0.001 |
|||
Model 1: Unadjusted model
Model 2: Multivariable adjusted logistic regression. Adjusted for age, sex, comorbidities, Na value at hospital admission, eGFR baseline
Model 3: Multivariable adjusted logistic regression. Adjusted for age, sex, comorbidities, Na value at hospital admission, eGFR baseline, Na lowest and highest peak value