Table 5:
Average values of representative pain and psychosocial measures within clusters predicted by ROPA.
| Feature | A (n=230) | PS (n=259) | GS (n=152) | P-value† | A v. PS‡ | PS v. GS‡ | A v. GS‡ | |
|---|---|---|---|---|---|---|---|---|
| DIPT | PEG Average Pain (0-10) | 5.11 (0.18) | 5.49 (0.14) | 6.64 (0.15) | 9.88E−09 | 1.00E−01 | 1.16E−07 | 5.23E−10 |
| PEG Interference Activity (0-10) | 4.75 (0.22) | 5.41 (0.19) | 6.95 (0.21) | 4.29E−11 | 1.96E−02 | 1.10E−07 | 2.53E−12 | |
| PEG Interference Enjoyment (0-10) | 5.51 (0.22) | 5.88 (0.17) | 7.51 (0.18) | 9.43E−11 | 1.78E−01 | 2.65E−10 | 7.91E−12 | |
| PainDETECT score (0-38) | 8.05 (0.46) | 11.38 (0.51) | 17.31 (0.69) | 0.00E+00 | 1.69E−06 | 3.40E−11 | 4.43E−24 | |
| PSS score (0-40) | 17.51 (0.24) | 17.44 (0.22) | 21.28 (0.3) | 0.00E+00 | 8.31E−01 | 2.09E−21 | 9.91E−20 | |
| Rating of catastrophic thinking (0-100) | 36.78 (1.91) | 37.78 (1.72) | 53.19 (2.14) | 9.87E−09 | 6.96E−01 | 4.27E−08 | 2.29E−08 | |
| Rating of effectiveness to decrease pain (0-100) | 49.78 (2.07) | 48.26 (1.69) | 40.26 (2.26) | 4.58E−03 | 5.69E−01 | 4.91E−03 | 2.05E−03 | |
| SPANE Positive score (6-30) | 23.43 (0.26) | 22.89 (0.26) | 17.45 (0.33) | 0.00E+00 | 1.42E−01 | 7.27E−32 | 2.05E−36 | |
| SPANE Negative score (6-30) | 12.48 (0.23) | 12.66 (0.24) | 18.25 (0.34) | 0.00E+00 | 5.97E−01 | 1.33E−32 | 2.17E−34 | |
| SPANE Affect balance (−24-24) | 10.94 (0.45) | 10.23 (0.44) | −0.8 (0.6) | 0.00E+00 | 2.58E−01 | 2.03E−37 | 9.13E−41 | |
| ISI sum score (0-28) | 7.78 (0.37) | 8.47 (0.38) | 14.33 (0.6) | 0.00E+00 | 1.89E−01 | 8.71E−15 | 1.01E−17 | |
| ESE sum score (0-24) | 5.83 (0.3) | 5.64 (0.28) | 8.12 (0.45) | 6.33E−07 | 6.36E−01 | 4.85E−06 | 3.15E−05 | |
| Feature | A (n=1426) | PS (n=2062) | GS (n=790) | P-value† | A v. PS‡ | PS v. GS‡ | A v. GS‡ | |
| OPPERA | PSS score (0-40) | 11.84 (0.14) | 15.23 (0.12) | 22.89 (0.19) | 0.00E+00 | 4.63E−68 | 9.45E−189 | 4.37E−304 |
| PSQI global score (0-21) | 4.08 (0.07) | 5.04 (0.06) | 8.69 (0.14) | 0.00E+00 | 2.54E−25 | 2.60E−104 | 4.81E−148 | |
| PILL score (0-270) | 28.27 (0.47) | 39.11 (0.48) | 70.81 (1.1) | 0.00E+00 | 3.28E−57 | 2.39E−119 | 8.30E−184 | |
| KOHN global score (0-120) | 67.29 (0.31) | 73.98 (0.24) | 77.73 (0.42) | 0.00E+00 | 2.26E−63 | 1.66E−14 | 2.24E−79 | |
| Feature | A (n=388) | PS (n=127) | GS (n=151) | P-value† | A v. PS‡ | PS v. GS‡ | A v. GS‡ | |
| CPPC | PSS score (0-40) | 12.91 (0.3) | 14.43 (0.48) | 22.61 (0.5) | 0.00E+00 | 8.20E−03 | 9.44E−26 | 6.36E−42 |
| Heat pain threshold | 43.96 (0.16) | 41.77 (0.3) | 42.05 (0.3) | 9.71E−14 | 9.02E−10 | 5.09E−01 | 5.99E−08 | |
| Heat pain tolerance | 47.02 (0.11) | 45.07 (0.26) | 45.32 (0.26) | 0.00E+00 | 5.50E−11 | 4.83E−01 | 1.02E−08 | |
| No. neck sites painful to palpation (0-14) | 0.8 (0.11) | 4.39 (0.4) | 6.6 (0.42) | 0.00E+00 | 6.02E−15 | 1.58E−04 | 2.38E−28 | |
| No. body sites painful to palpation (0-14) | 1.73 (0.16) | 6.85 (0.4) | 8.33 (0.37) | 0.00E+00 | 7.44E−24 | 7.49E−03 | 1.24E−38 | |
| KOHN global score (0-120) | 74.81 (0.54) | 79.02 (1.03) | 83.39 (1.01) | 8.37E−14 | 4.83E−04 | 3.21E−03 | 3.52E−12 | |
| PCS global score (0-52) | 8.68 (0.42) | 11.95 (0.78) | 22.99 (0.98) | 0.00E+00 | 3.24E−04 | 4.00E−16 | 6.65E−29 | |
| PILL score (0-270) | 36.1 (1.09) | 56.26 (2.15) | 91.58 (2.81) | 0.00E+00 | 3.10E−14 | 1.38E−19 | 2.61E−43 | |
| POMS overall negative subscale | 52.65 (0.82) | 54.94 (1.25) | 79.83 (1.47) | 0.00E+00 | 1.32E−01 | 8.32E−29 | 2.21E−38 | |
| PSQI global score (0-21) | 4.85 (0.16) | 7.27 (0.36) | 10.67 (0.31) | 0.00E+00 | 1.34E−08 | 8.14E−11 | 2.79E−36 |
Note: These variables were not used in developing the cluster solutions. Additional measures obtained in the CPPC cohort are presented in Appendix Table 5. See [4] for additional measures obtained in the OPPERA cohort.
†
Indicates that the p-value tests the null hypothesis that the mean value of the measure does not differ between the three clusters.
‡
Indicates that the p-value tests the null hypothesis that the mean value of the measure does not differ between the two compared clusters.