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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Small. 2020 Oct 23:e2004258. doi: 10.1002/smll.202004258

Figure 5. Crucial role of interaction between BC and cardiac tissues in regulating production rates of biomarkers.

Figure 5.

a) Schematic illustration displaying i) disconnected and ii) connected breast cancer-cardiac tissues on chip. b) Troponin T and c) CK-MB production rates in iPSC-derived healthy cardiac tissues for 5 days on single or dual chips using ELISA (N= 3). d) ELISA measurement of HER-2 rate in BC tissues on single or dual (with healthy cardiac tissues) chips (N= 3). e) Troponin T and f) CK-MB production rates in iPSC-derived fibrotic cardiac tissues for 5 days on single or dual chips using ELISA (N= 3). g) ELISA measurement of HER-2 rate in BC tissues on single or dual (with fibrotic cardiac tissues) chips (N= 3). (One-way ANOVA with Tukey significant difference post-hoc test; *p<0.05, **p<0.005, and ***p<0.0005). Error bars represent standard deviation.