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. 2021 Apr 15;11:8279. doi: 10.1038/s41598-021-87441-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Predominant dysregulation of miRNA isoforms in EVs from NEPC. (A) Heat map showing differentially expressed iso-miRs in EVs from CRPC-adeno cases (n = 21) as compared to CRPC-NE (n = 6 clinical tissues + NCI-H660 cell line). Heat map was generated by using R studio software, Version 1.1.463 (https://www.npackd.org/p/rstudio/1.1.463). (B) miRNA loci producing ≥ 3 differentially expressed iso-miRs in sequenced samples plotted as a function of number of observed iso-miRs. (C) Range of length of differentially expressed iso-miRs (14–24 nucleotides) and their abundance across sequenced EV miRNAs extracted from CRPC-Adeno and CRPC-NE samples.