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. 2021 Apr 15;12:2277. doi: 10.1038/s41467-021-22266-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, d, g Genome browser view of Shroom3, Dab2, and Uncx loci; from top to bottom: mouse orthologue of eGFR GWAS significant SNPs (after lift-over) mouse kidney single nuclei chromatin accessibility for nephron progenitors (NP), podocytes (Podo), proximal convoluted and straight tubules (PCT and PST), loop of Henle (LOH), distal convoluted tubule (DCT), collecting duct intercalated cells (IC), collecting duct principal cell types (PC), endothelial cells (Endo), immune cells (Immune) and stromal cells (Stroma). Data range in all tracks is set to the same scale. Examples of cell type-specific accessible chromatin overlapped with significant SNPs are highlighted with dashed lines. Right subpanel shows violin plots of cell type-specific gene expression in P0 (orange) and adult (blue) kidneys in the scRNA-seq dataset. b, e, h Corresponding genome browser views in adult human (hg19) kidney snATAC-seq data; from top to bottom: eGFR GWAS significant SNPs, adult human kidney single nuclei chromatin accessible landscape, whole kidney H3K27ac, H3K4me1, and H3K4me3 ChIP-seq tracks. The genomic location in human was matched to the mouse orthologue. Note that for DAB2 (f), the image was mirrored to facilitate comparison along genomic read direction. Alternative genome browser views at more zoomed-in locations are available in Supplementary Fig. 23. c, f, i Whole mouse kidney epigenomics tracks from E14.5, E15.5, E16.5, P0, and adult mice. From top to bottom: H3K27ac, H3K4me1, H3K4me3, and Six2 ChIP-seq; whole genome bisulfate sequencing (WGBS); and bulk RNA-seq. The bottom Refseq visualization corresponds to the Refseq track at the top in a, d, g, respectively. Six2 binding signal in nephron progenitor cells.