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. 2021 Apr 15;11:8215. doi: 10.1038/s41598-021-87559-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Flight-like responses in rats are specific to white noise and not due to sensitization. (A) Behavioral design. (B) Average freezing and activity data showing that flight-like behavior is specific to the white noise stimulus regardless of the temporal of order of the SCS. In a Reversed order SCS, rats show a decrease in freezing and corresponding increase in activity to the first stimuli (noise) rather than the second (tone). The data additionally show that unpairing the SCS and US with a 60-s gap (Unpaired) prevents flight-like behavior compared to Standard SCS-US controls. This all further shown by averaged activity time across time (C). All data are represented as mean ± SEM pooled across sex [Standard (n = 7); Reverse (n = 8); Unpaired (n = 8)]; *, **, and *** denote p < 0.05, p < 0.01, and p < 0.001, respectively.