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. 2021 Apr 15;11:8317. doi: 10.1038/s41598-021-87952-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ChemRICH diagram according to the strain resistance. Each disc reflects a significantly altered family of metabolites. These groups are developed from chemical similarities highlighted by a hierarchical Tanimoto map (not shown) accessible in the ChemRICH program. Enrichment p-values are given by the Kolmogorov–Smirnov test. Disc sizes varies with the total number of metabolites. Blue or red discs present groups of overexpressed or underexpressed metabolites in Res compared to Std animals, respectively. Purple color represents both increased and decreased metabolites. For example, there are less disaccharides in the feces of the DCS-resistant rats.