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. 2021 Apr 15;11:8232. doi: 10.1038/s41598-021-87740-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Terpene Induced Catalepsy is Partially Mediated by CB1, Strongly Mediated by A2a, and is Partially Additive with Cannabinoid. Mice were baselined in the ring test for 5 min, injected with 200 mg/kg terpene alone, combined with 5.6 mg/kg WIN55,212-2, or after pretreatment with 10 mg/kg rimonabant or 10 mg/kg istradefyllene. After 15 min, mice were tested in the ring test again for 5 min. (A) α-Humulene, (B) β-Pinene, (C) Linalool and (D) Geraniol. Data represents the mean ± SEM of % catalepsy (n = 10–20/group). Statistics analyzed via RM two-way ANOVA, Tukey’s post hoc; **p < 0.01, ***p < 0.001, ****p < 0.0001, not significant (ns) compared to baseline; x p < 0.05, xx p < 0.01, xxx p < 0.001, xxxx p < 0.0001 compared to terpene post-treatment. The dashed line represents the cataleptic response to 5.6 mg/kg WIN55,212-2 alone, taken from Fig. S2B.