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. 2021 Apr 15;11:8232. doi: 10.1038/s41598-021-87740-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Terpene Induced Hypolocomotion is Partially Mediated by A2a and is Additive with Cannabinoid. Mice were injected with 200 mg/kg terpene alone, combined with 5.6 mg/kg WIN55,212-2, or after pretreatment with 10 mg/kg rimonabant or 10 mg/kg istradefyllene, i.p.. After 10 min mice were then placed back into the open field box for a 5 min test. (A) α-Humulene, (B) β-Pinene, (C) Linalool and (D) Geraniol. Data represents the mean ± SEM of mobile time seconds (n = 10–20/group). Statistics analyzed via one-way ANOVA, Dunnett’s post hoc; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 compared to terpene alone. The black dotted line denotes vehicle levels of mobile time for reference, while the red dotted line represents the effect of 5.6 mg/kg WIN55,212-2 alone, both taken from Fig. S3A.