Table 2.

Summary of estrogen receptor gene polymorphisms relating to vascular dementia

ER subtype, gene	Polymorphism/SNPs examined	Ethnicity	Main finding(s)	Reference
ERα, ESR1	PvuII and XbaI	–	No significant difference in VaD patients vs. controls; significantly increased in late-onset AD	[13]
ERβ, ESR2	ESR2 rs4986938	Jewish	Association of ESR2 rs4986938 and VaD in elderly women (n = 60; age 82 ± 6)	[15]
ERβ, ESR2	ESR2 rs944050 and ESR2 rs4986938	Chinese Han	Association of ESR2 rs944050 and increased risk of VaD in women (n = 61; age > 50)	[14]