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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: J Neurochem. 2020 Nov 2;157(6):1809–1820. doi: 10.1111/jnc.15219

Figure 1. Translational machinery and RNA interacting proteins are upregulated in membrane fractions of Nedd4-2 cKO brains.

Figure 1.

(A) Representative western blot showing the efficiency of Nedd4-2 reduction in whole brains and isolated membrane fractions. The quantification is on the right. (B) A pie chart summarizing the results of the proteomics screen of the membrane isolated fractions from Nedd4-2 WT and Nedd4-2 cKO mouse brains. (C) A bar graph identifying the top cellular functions of the proteins identified in the proteomics screen. (D) Heat maps showing the upregulation of RNA interacting proteins in Nedd4-2 cKO brains (D1), as well as heat maps of these proteins based on further functional subclassification (D2-D5).