Table 2.

Associations of subtypes of PA and ST with volumes of the total brain and white matter

	Total brain volume		White matter volume
	stβ (95% CI)	P	stβ (95% CI)	P
LPA time (high to low)
Model 1	− 0.019 (− 0.033, − 0.006)	0.005	0.003 (− 0.019, 0.025)	0.784
Model 2	− 0.012 (− 0.025, 0.002)	0.092	0.011 (− 0.012, 0.033)	0.353
Model 3	− 0.008 (− 0.022, 0.005)	0.230	0.010 (− 0.013, 0.033)	0.395
HPA time (high to low)
Model 1	− 0.013 (− 0.027, 0.001)	0.065	0.003 (− 0.020, 0.026)	0.821
Model 2	− 0.005 (− 0.019, 0.009)	0.506	0.011 (− 0.013, 0.034)	0.365
Model 3	− 0.003 (− 0.017, 0.011)	0.687	0.010 (− 0.014, 0.034)	0.423
Sedentary time (low to high)
Model 1	− 0.022 (− 0.037, − 0.008)	0.002	− 0.008 (− 0.032, 0.016)	0.492
Model 2	− 0.013 (− 0.028, 0.001)	0.073	0.001 (− 0.024, 0.025)	0.963
Model 3	− 0.010 (− 0.024, 0.005)	0.200	0.001 (− 0.024, 0.026)	0.944

Associations between physical activity measures (minutes/day) with brain volumes. Regression coefficients and 95% CI indicate the mean difference in volume per SD. Higher LPA, HPA, or lower sedentary time. Model 1, adjusted for age, sex, education level, MRI lag time, wake time, and ICV. Model 2, additionally adjusted for diabetes status. Model 3, additionally adjusted for BMI, systolic blood pressure, antihypertensive medication, total-to-HDL-cholesterol ratio, lipid-modifying medication, smoking status, alcohol use, and history of cardiovascular disease

Italic values indicate p<0.05