Table 3.

Associations of low- and high-intensity physical activity time and high sedentary time with whole brain node degree

	Whole brain node degree
	stβ (95% CI)	P value
LPA time (high to low)
Model 1	− 0.035 (− 0.081, 0.011)	0.137
Model 2	− 0.022 (− 0.069, 0.025)	0.356
Model 3	− 0.013 (− 0.061, 0.034)	0.580
HPA time (high to low)
Model 1	− 0.081 (− 0.128, − 0.033)	0.001
Model 2	− 0.068 (− 0.116, − 0.021)	0.005
Model 3	− 0.062 (− 0.112, − 0.013)	0.014
Sedentary time (low to high)
Model 1	− 0.052 (− 0.101, − 0.002)	0.039
Model 2	− 0.037 (− 0.087, 0.013)	0.152
Model 3	− 0.030 (− 0.081, 0.021)	0.250

Associations of physical activity measures with whole brain node degree. Standardized regression coefficients and 95% CI indicate the mean difference in node degree per SD lower physical activity and higher sedentary time. Model 1, adjusted for age, sex, education level, MRI lag time, and wake time. Model 2, additionally adjusted for diabetes status. Model 3, additionally adjusted for BMI, systolic blood pressure, antihypertensive medication, total-to-HDL-cholesterol ratio, lipid-modifying medication, smoking status, alcohol use, and history of cardiovascular disease

Italic values indicate p<0.05