Table 5.

Associations of low- and high-intensity physical activity time and high sedentary time with node degree of the basal ganglia and the primary motor cortex

	Degree		Degree
	Basal ganglia		Primary motor cortex
	stβ (95% CI)	P	stβ (95% CI)	P
LPA time (high to low)
Model 1	− 0.067 (− 0.116, − 0.019)	0.006	− 0.038 (− 0.085, 0.010)	0.118
Model 2	− 0.053 (− 0.102, − 0.004)	0.032	− 0.017 (− 0.065, 0.031)	0.487
Model 3	− 0.049 (− 0.098, 0.001)	0.056	− 0.017 (− 0.066, 0.032)	0.489
HPA time (high to low)
Model 1	− 0.085 (− 0.134, − 0.035)	0.001	− 0.052 (− 0.101, − 0.003)	0.037
Model 2	− 0.070 (− 0.121, − 0.020)	0.006	− 0.030 (− 0.079, 0.019)	0.232
Model 3	− 0.070 (− 0.121, − 0.018)	0.009	− 0.035 (− 0.086, 0.016)	0.178
Sedentary time (low to high)
Model 1	− 0.052 (− 0.103, 0.000)	0.049	− 0.033 (− 0.084, 0.017)	0.197
Model 2	− 0.034 (− 0.087, 0.018)	0.203	− 0.008 (− 0.060, 0.044)	0.761
Model 3	− 0.029 (− 0.082, 0.025)	0.295	− 0.008 (− 0.061, 0.045)	0.759

Associations of physical activity measures with node degree of the basal ganglia and primary motor cortex. Regression coefficients and 95% CI indicate the mean difference in node degree per SD lower physical activity and higher sedentary time. Model 1, adjusted for wake time, age, sex, education level, MRI lag time. Model 2, additionally adjusted for diabetes status. Model 3, additionally adjusted for BMI, systolic blood pressure, antihypertensive medication, total-to-HDL-cholesterol ratio, lipid-modifying medication, smoking status, alcohol use, and history of cardiovascular disease

Italic values indicate p<0.05