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Age-dependent role of Pg-LPS on secretion of some pro-inflammatory SASP cytokines, including TNF-α (a), IL-1β (b), IL-6 (c), and osteoclastogenic factor, RANKL (d) in periodontal lesions of young and aged wild-type mice. Gingival tissues were sampled from the inflamed periodontal sites of young and aged mice and then were evaluated by ELISA. *p < 0.05, **p < 0.01; ***p < 0.001
