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. 2021 Apr 15;11:8217. doi: 10.1038/s41598-021-87548-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cnnm2 deficiency decreases faecal Mg²⁺ absorption. (A,C) Cnnm2^+/− mice display significantly increased Mg²⁺ and Ca²⁺ excretion via the faeces (n = 29–34 per group). (B,D) Lower Mg²⁺ intake is associated with lower intestinal Mg²⁺ excretion, not with Ca²⁺, independent of genotype in Cnnm2^+/+ (white bars) and Cnnm2^+/− mice (black bars) (n = 8–12 per group) (E) Cnnm2 expression is significantly diminished in Cnnm2^+/− mice, Cnnm4 (G), Trpm6 (H), Trpm7 (I), Slc41a1 (J), and Trpv6 (K) remain unaltered (n = 3–6 per group). Data are presented as mean ± SEM. Significance determined with two-tailed Student’s T-test or Two-way ANOVA followed by a Tukey post-hoc test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.