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. 2021 Apr 15;11:8253. doi: 10.1038/s41598-021-87683-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of H3K4me3 modifications common in blastocysts and liver in terms of imprinted genes. (a) Average profile plot of the H3K4me3 signal around the TSSs of 30 imprinted genes. (b) PCA of liver and blastocyst samples considering the peak areas around the 30 TSSs of the imprinted genes and two additional DMRs. Left and right panels show the principal component plot of all samples and loading plot of the loci examined, respectively. The genes whose H3K4me3 landscapes are shown in (c) are highlighted in red. (c) H3K4me3 landscapes of GATM, IGF2R, IGF2R/AIRN (DMR), KCNQ1OT1 (DMR), and IMPACT. Five-kb graduations are shown in the top scale.