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. 2021 Apr 15;11:8298. doi: 10.1038/s41598-021-87921-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Statistically significant relationship (nonparametric Kruskal–Wallis test) between Child–Pugh class and (A) fetal bile acid 1 (FBA1) plasma concentration (ng/mL), (B) fetal bile acid 2 (FBA2) plasma concentration (ng/mL) and statistically significant correlations (simple linear regression) between Child–Pugh score and (C) FBA1 plasma concentration, (D) FBA2 plasma concentration and (E) the sum of FBA1 and FBA2 plasma concentrations. C-P mean Child–Pugh. Black symbols represent LC patients without HCC and red symbols represent LC patients with HCC. Dotted lines represent 95% confidence intervals.