Table 2.

Comparison of the changes of mutation rates from baseline between the T-705-treated group and the control group at days 2 and 4 since treatment

	Days since treatment	Changes from baseline		Difference between two groups	P value
		Control group	T-705-treated group
Total mutation rate, mean (CI 95%), %	2	0.14 (0.02 to 0.26)	0.19 (−0.03 to 0.41)	0.05 (−0.18 to 0.28)	0.663
	4	0.14 (−0.01 to 0.29)	0.89 (0.22 to 1.55)	0.75 (0.08 to 1.42)	0.033
Transition mutation rate, mean (CI 95%), %	2	0.11 (0.01 to 0.21)	0.15 (-0.03 to 0.33)	0.04 (−0.15 to 0.23)	0.675
	4	0.12 (−0.01 to 0.26)	0.74 (0.18 to 1.29)	0.61 (0.05 to 1.17)	0.035
Transversion mutation rate, mean (CI 95%), %	2	0.02 (−0.03 to 0.06)	0.04 (-0.01 to 0.08)	0.02 (-0.03 to 0.08)	0.375
	4	0.02 (−0.01 to 0.04)	0.15 (0.04 to 0.27)	0.13 (0.02 to 0.25)	0.029