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. 2021 Apr 2;12:642528. doi: 10.3389/fimmu.2021.642528

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Copyright © 2021 Lin, Cheng, Ye, Li, Zheng, Qin, Wu, Long, Lin, Wang, Huang, Li, Yao and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Murine CTLA4-chimeric T cells show toxicity against MDSCs. (A) Statistical analysis of MDSCs percentage with tumors by flow cytometry, mean ± SD, one-way ANOVA. (B) Representative flow cytometric analysis of the expression of CD80 and CD86 on MDSCs after CTLA4-CAR T cell therapy. (C) Weight change of autologous mice (n = 5) after T cell transfer. (D) Mice were monitored for GVHD pathology score twice a week. (E) H&E staining of organs, scale bar, 100 μm. Significance values: ***P < 0.001.