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CTLA4-chimeric T cells elicited mild CRS in vivo. (A) Weight change of tumor-bearing mice (n = 5) after T cell transfer, two-way ANOVA with Tukey’s multiple comparison test. (B) Percent survival of mice after CAR T cell transfer (n=5 mice for each group). (C–E) Serum levels of mIL-6, hIL-2, and hIFN-γ 24 and 48 h post CAR T cell transfer were measured by ELISA. Significance values: *P < 0.05; **P < 0.01; ***P < 0.001; ns, non-significance.
