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. 2021 Apr 2;11:640448. doi: 10.3389/fcimb.2021.640448

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Copyright © 2021 Gao, Zhang, Xiao, Ren, Yan, Yue, Wang, Wu, Lv and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bacterial 16S rRNA-based analysis of the intestinal microbiota of CD- and HFD-fed rats. (A) PCoA plot showing the unweighted UniFrac distance between CD- and HFD-fed rats. Each rat is identified by a point. (B) Shannon-Weiner index representing the alpha-diversity in CD- and HFD-fed rats. (C) Pie charts showing the relative abundance of phyla in the fecal microbiota of CD and HFD-fed rats (Kruskall Wallis test). (D) Cladogram showing the taxa most differentially associated with CD- (green) or HFD-fed (red) rats (Wilcoxon rank-sum test). Circle sizes in the cladogram plot are proportional to bacterial abundance. The circles represent, going from the inner circle to the outer circle: phyla, class, order, family and genus. CD, n=6; HFD, n=8 CD, Control diet; HFD, High fat diet; OTU, operational taxonomic unit.