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. 2021 Mar 17;24(4):102321. doi: 10.1016/j.isci.2021.102321

Figure 6.

Figure 6

Schematic of the role of Cbl and Cbl-b and associated signaling proteins in regulation of ERK phosphorylation and neurite outgrowth in neuroblastoma cells

Models summarizing the role of Cbl and Cbl-b in negative regulation of ERK phosphorylation and neurite outgrowth in the SH-SY5Y neuroblastoma cells. The schematics illustrate the identified signaling proteins and how inhibition of these proteins revealed their implication in Cbl/Cbl-b-dependent regulation of ERK phosphorylation and neurite outgrowth.