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. 2021 May 1;25(3):197–206. doi: 10.4196/kjpp.2021.25.3.197

Fig. 3. Carnosol inhibits the differentiation of mouse bone marrow-derived mesenchymal stem cells (mBMSCs) into adipocytes.

Fig. 3

(A) Inhibitory effect of carnosol on adipogenesis of mBMSCs as measured by Oil Red O staining for fat droplets formation. mBMSCs were induced to differentiated into adipocytes either in the presence of DMSO (I) as control or different concentrations of carnosol. Scale bars = 100 µm. (B) Quantification of Oil Red O staining after 12 days of differentiation. (C) Quantitative real-time PCR analysis of the adipogenic specific genes expression in the differentiated mBMSCs into adipocytes in the presence of different concentrations of carnosol. Gene expression values were normalized to reference genes and represented as fold inhibition to induced cells without carnosol. Values are mean ± standard deviation of three independent experiments (*p < 0.05, **p < 0.005, compared to [I]).