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. 2021 Mar 10;19:1759–1785. doi: 10.1016/j.csbj.2021.03.003

Table A2.

Quality assessment of the included studies according to the Quality assessment tool for observational cohort and cross-sectional studies.

Work Q1 Q2 Q3 Q4 Q5 Q6 Q7 Q8 Q9 Q10 Q11 Q12 Q13 Q14 Quality
High-level serum uric acid
[14] Yes Yes Yes Yes No Yes Yes Yes Yes Yes* NR NR Yes Yes Good
[21] Yes Yes NR Yes No CD No No NR No CD NR No Yes Poor
[22] Yes Yes Yes CD No Yes Yes CD Yes Yes No NR No Yes Fair
[23] No Yes NR Yes No Yes Yes CD Yes Yes Yes NR CD Yes Fair
[19] No No NR NR No Yes CD No NR Yes NR NR NR No Poor
[15] No Yes NR Yes No Yes Yes Yes Yes Yes Yes NR NR Yes Good
[24] No Yes NR Yes No Yes Yes Yes Yes Yes Yes NR NR Yes Good
[16] Yes Yes NR Yes No Yes Yes Yes NR Yes NR NR NR Yes Fair
[25] Yes Yes NR No No Yes Yes No Yes Yes Yes NR NR Yes Fair
[26] Yes Yes NR Yes No Yes Yes No Yes Yes Yes NR Yes Yes Fair
[27] Yes No NR CD No Yes Yes No Yes Yes Yes NR NR Yes Fair
[30] No Yes NR Yes No No No Yes Yes NR Yes NR NR Yes Fair
Sleep quantity/quality
[79] Yes Yes NR Yes No Yes Yes Yes No Yes Yes NR NR Yes Fair
[56] No No NR Yes No Yes Yes NA No Yes Yes NR Yes Yes Fair
[57] Yes Yes NR Yes No Yes Yes NA No No No NR NR Yes Fair
[59] Yes Yes Yes Yes No Yes Yes NA No No Yes NR NR Yes Good
[83] No Yes NR Yes No No No Yes No NR Yes NR NR Yes Fair
[52] Yes Yes Yes Yes No Yes Yes Yes No No No NR Yes Yes Fair
[50] Yes Yes Yes Yes No Yes Yes No No Yes Yes NR No Yes Fair
[85] Yes Yes NR Yes No Yes Yes Yes No Yes NR NR No Yes Fair
[87] Yes Yes NR Yes No Yes Yes Yes No Yes No NR Yes Yes Fair
[89] Yes Yes NR Yes No No No Yes No No Yes NR NR Yes Fair
[58] Yes Yes No Yes No Yes Yes Yes No CD Yes NR NR Yes Fair
[92] Yes Yes NR Yes No No No Yes No NR Yes NR NR Yes Fair
[94] Yes Yes NR Yes No Yes Yes Yes No NR Yes NR NR Yes Fair
[55] Yes Yes No Yes No Yes Yes Yes No No Yes NR Yes Yes Fair
[96] CD Yes Yes No No No No Yes No NR Yes NR CD Yes Fair
[97] Yes No No Yes No Yes Yes Yes No NR Yes NR NR Yes Fair
[98] Yes Yes CD Yes No Yes Yes Yes No No No NR NR Yes Fair
[100] Yes Yes NR CD No No No Yes No NR Yes NR NR Yes Fair
[51] No Yes CD Yes No Yes No Yes No Yes No NR Yes Yes Fair
[102] Yes Yes NR Yes No Yes Yes Yes No NR No NR Yes Yes Fair
[53] Yes Yes Yes No No No No Yes No NR No NR NR Yes Fair
[104] Yes Yes NR CD No No No Yes No NR Yes NR NR Yes Fair
[106] Yes Yes Yes Yes No Yes Yes Yes No Yes Yes NR No Yes Good
[54] Yes Yes Yes No No No No Yes No Yes No NR NR Yes Fair
[108] Yes Yes No Yes No Yes NR No No NR No NR NR Yes Poor
Smoking
[110] No Yes NR Yes No Yes Yes No NA Yes No NR NR Yes Fair
[67] No Yes NR Yes No Yes Yes Yes NA Yes Yes Yes NR Yes Good
[68] Yes Yes NR Yes No Yes Yes Yes NA Yes Yes No Yes Yes Good
[112] No No Yes Yes No Yes Yes Yes NA Yes Yes NR Yes Yes Good
[73] CD Yes NR Yes No No No Yes NA NR No NR NR Yes Poor
[114] Yes Yes NR Yes No Yes Yes Yes NA Yes Yes NR Yes Yes Good
[69] Yes Yes NR Yes No Yes Yes Yes NA Yes No Yes NR Yes Good
[116] No Yes NR Yes No No No No NA NR Yes NR NR Yes Poor
[65] Yes Yes NR Yes No Yes Yes No NA Yes Yes NR Yes Yes Fair
[63] Yes Yes NR Yes No Yes Yes Yes NA NR CD NR NR Yes Fair
[119] No Yes No Yes No Yes Yes Yes NA Yes Yes NR Yes Yes Good
[120] No CD NR CD No Yes Yes Yes NA Yes NR NR NR Yes Fair
[74] Yes Yes Yes CD No No No No NA No Yes NR NR Yes Fair
[122] Yes Yes Yes Yes No Yes Yes No NA No Yes No No Yes Good
[70] Yes Yes No Yes No Yes Yes No NA No Yes NR NR Yes Fair
[77] Yes Yes Yes Yes No Yes Yes Yes NA Yes Yes NR CD Yes Good
[71] Yes CD Yes Yes No Yes Yes Yes NA Yes Yes NR NR Yes Good
[75] Yes Yes NR Yes No Yes Yes Yes NA Yes Yes NR NR Yes Good
[66] No Yes Yes Yes No Yes Yes No NA No Yes NR No Yes Good
[64] Yes Yes NR Yes No Yes Yes Yes NA Yes CD NR NR Yes Fair
[72] Yes No NR CD No Yes Yes Yes NA Yes Yes NR Yes Yes Good
[78] Yes Yes Yes Yes No Yes Yes No NA Yes Yes NR Yes Yes Good
[76] Yes Yes NR Yes No Yes Yes Yes NA Yes Yes NR Yes Yes Good
[128] No Yes NR Yes No Yes Yes No NA NR No NR NR Yes Fair
Depression
[137] Yes Yes Yes Yes No Yes Yes Yes Yes No Yes NR Yes Yes Good
[155] No Yes NR Yes No Yes Yes No Yes No No NR NR Yes Fair
[157] Yes Yes NR Yes No Yes Yes Yes No NR No NR NR Yes Fair
[158] Yes Yes NR Yes No Yes Yes Yes Yes NR Yes NR NR Yes Fair
[136] Yes Yes NR Yes No Yes CD No Yes Yes Yes NR CD Yes Fair
[160] Yes Yes Yes Yes No Yes Yes No Yes Yes Yes NR NR Yes Good
[138] No Yes NR Yes No Yes Yes No Yes No CD NR NR Yes Fair
[139] No Yes NR Yes No Yes Yes No Yes No Yes NR NR Yes Fair
Cardiovascular disease
[141] No Yes NR Yes No Yes Yes Yes Yes Yes Yes NR NR Yes Good
Dyslipidemia
[148] Yes Yes NR Yes No Yes Yes Yes CD CD No NR No Yes Fair
[154] Yes Yes NR Yes No Yes Yes Yes NR NR NR NR Yes Yes Fair
[152] No Yes NR Yes No Yes CD Yes Yes No Yes NR Yes Yes Fair
Hypertension
[166] Yes Yes NR Yes No Yes Yes Yes Yes NR Yes NR Yes Yes Good
[167] Yes Yes NR Yes No Yes Yes Yes Yes No Yes NR NR Yes Good
[168] Yes Yes NR Yes No Yes Yes Yes No No No NR CD Yes Fair
[170] Yes Yes NR No No Yes Yes Yes Yes No Yes NR NR Yes Good
[188] Yes Yes Yes Yes No Yes Yes Yes Yes No Yes NR CD Yes Good
[169] Yes Yes Yes Yes No Yes Yes Yes Yes No Yes NR NR Yes Good
Ethnicity
[177] No Yes Yes No No No No NA NA NR Yes NR NR Yes Fair
[179] No Yes Yes No No No No NA NA NR NR NR NR Yes Poor
[180] No Yes Yes No No No No NA NA No Yes NR NR Yes Fair
[181] Yes Yes Yes CD No No No NA NA No Yes NR NR Yes Fair
[175] Yes Yes Yes Yes No No No NA NA No No NR NR Yes Poor
[176] Yes Yes NR Yes No Yes Yes NA NA Yes Yes NR NR Yes Good
Family history of diabetes
[204] No No NR CD No Yes NR No Yes NA Yes NR NR Yes Fair
[195] Yes Yes Yes Yes No No No Yes No NA Yes NR NR Yes Fair
[200] Yes Yes NR Yes No Yes Yes Yes No NA Yes NR NR Yes Fair
[205] No Yes NR No No Yes CD Yes NR NA NR NR NR No Poor
[194] No Yes NR Yes No Yes Yes No NR NA Yes NR NR Yes Fair
[201] Yes Yes Yes Yes No Yes Yes Yes CD NA Yes NR Yes Yes Good
[198] Yes Yes NR Yes No No No No No NA Yes NR NR Yes Poor
[202] No Yes NR Yes No Yes Yes Yes Yes NA Yes NR NR Yes Good
[203] Yes Yes Yes No No No No Yes No NA No NR NR Yes Fair
[197] Yes Yes NR Yes No No No Yes No NA Yes NR NR Yes Fair
[199] Yes Yes No No No No No Yes Yes NA Yes NR NR Yes Fair
[196] Yes Yes Yes Yes No No No No Yes NA Yes NR NR Yes Fair
[193] Yes Yes Yes Yes No CD NR No No NA Yes NR NR Yes Fair
Obesity
[206] Yes Yes NR Yes No Yes Yes Yes Yes Yes Yes NR NR Yes Good
[213] Yes Yes NR Yes No Yes Yes No Yes Yes Yes NR Yes Yes Fair
[119] No Yes No Yes No Yes Yes Yes NA Yes Yes NR Yes Yes Good
[207] No No NR CD No Yes Yes Yes NR NR Yes NR NR Yes Fair
[208] No Yes NR Yes No Yes Yes No Yes NR Yes NR NR Yes Fair
[209] Yes Yes Yes Yes No Yes Yes No Yes NR Yes NR No Yes Good
[210] Yes Yes Yes Yes No CD CD No Yes NR Yes NR NR Yes Fair
[211] Yes Yes NR Yes No Yes CD No Yes NR Yes NR NR Yes Fair

Q1. Was the research question or objective in this paper clearly stated?.

Q2. Was the study population clearly specified and defined?.

Q3. Was the participation rate of eligible persons at least 50%?

Q4. Were all the subjects selected or recruited from the same or similar populations (including the same time period)? Were inclusion and exclusion criteria for being in the study prespecified and applied uniformly to all participants?.

Q5. Was a sample size justification, power description, or variance and effect estimates provided?.

Q6. For the analyses in this paper, were the exposure(s) of interest measured prior to the outcome(s) being measured?.

Q7. Was the timeframe sufficient so that one could reasonably expect to see an association between exposure and outcome if it existed?.

Q8. For exposures that can vary in amount or level, did the study examine different levels of the exposure as related to the outcome (e.g., categories of exposure, or exposure measured as continuous variable)?.

Q9. Were the exposure measures (independent variables) clearly defined, valid, reliable, and implemented consistently across all study participants?.

Q10. Was the exposure(s) assessed more than once over time?.

Q11. Were the outcome measures (dependent variables) clearly defined, valid, reliable, and implemented consistently across all study participants?.

Q12. Were the outcome assessors blinded to the exposure status of participants?.

Q13. Was loss to follow-up after baseline 20% or less?.

Q14. Were key potential confounding variables measured and adjusted statistically for their impact on the relationship between exposure(s) and outcome(s)?.

CD-Cannot be Determined; NA-Not Applicable; NR-Not Reported.