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. 2021 Apr 14;220(6):e202011014. doi: 10.1083/jcb.202011014

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© 2021 Vessoni et al.

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Figure 1. — hPSCs and fibroblasts adopt different fates in response to telomere (Tel.) attrition. (A) β-gal activity assay. (B and C) EdU incorporation (percentage and absolute number of EdU⁺ cells is indicated in each image; B) and cell cycle analysis (C) performed in iTERT and iTERT_TP53/RB1 KO hPSCs and their isogenic fibroblasts with long and short telomeres. PDL for cells with short telomeres: 149–159 (iTERT hPSCs); 205–215 (iTERT_TP53/RB1 KO hPSCs); 45–47 (iTERT fibroblasts); and 95–97 (iTERT_TP53/RB1 KO fibroblasts).